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FLASH GENE
Symbol DPM3 contributors: mct/npt - updated : 25-08-2009
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 3
HGNC id 3007
Corresponding disease
CDG1O congenital disorder of glycosylation 1O
Location 1q21.2      Physical location : 155.112.368 - 155.112.996
Synonym name
  • prostin 1
  • DPM synthase complex subunit 3
  • mannose-P-dolichol synthase subunit 3
  • Synonym symbol(s) MGC34275, MGC125904, MGC125905
    EC.number 2.4.1.83
    DNA
    TYPE functioning gene
    STRUCTURE 0.63 kb     2 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PMVK 1p13-q23 phosphomevalonate kinase PBXIP1 1q22 pre-B-cell leukemia transcription factor interacting protein 1 PYGO2 1q22 pygopus 2 SHC1 1q21 SHC (Src homology 2 domain containing) transforming protein 1 CKS1B 1q21.2 CDC28 protein kinase regulatory subunit 1B PP591 1q22 FAD-synthetase LENEP 1q22 lens epithelial protein ZFP67 1q21.2 zinc finger protein 67 homolog (mouse) FLJ32934 1q22 hypothetical protein FLJ32934 FLJ32785 1q22 hypothetical protein FLJ32785 ADAM15 1q21.3 a disintegrin and metalloproteinase domain 15 (metargidin) EFNA4 1q21-q22 ephrin-A4 EFNA3 1q21-q22 ephrin-A3 EFNA1 1q21-q22 ephrin-A1 LOC55974 1q22 stromal cell protein DPM3 1q21.2 dolichyl-phosphate mannosyltransferase polypeptide 3 KCP2 TRIM46 1q21-22 tripartite motif-containing 46 MUC1 1q21 mucin 1, transmembrane THBS3 1q21-q23 thrombospondin 3 MTX1 1q21 metaxin 1 LOC388704 1 similar to GBA protein MTX1P 1q21 metaxin 1 pseudogene GBA 1q21 glucosidase, beta; acid (includes glucosylceramidase) C1orf2 1q21 chromosome 1 open reading frame 2 SCAMP3 1q21 secretory carrier membrane protein 3 CLK2 1q21 CDC-like kinase 2 HCN3 1q22 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 PKLR 1q21 pyruvate kinase, liver and RBC FDPS 1q21.2 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) FLJ35976 1q22 hypothetical protein FLJ35976 RUSC1 1q21-q22 RUN and SH3 domain containing 1 ASH1L 1q21 ash1 (absent, small, or homeotic)-like (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 417 10 92 - Gregory (2006)
    1 - 532 13.1 122 - Gregory (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   moderately
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • two putative N terminal transmembrane domains, showed no specific functions
  • one hydrophilic C terminal portion
  • near the C terminus, a coiled-coil domain for DPM1 binding (Lefeber 2009) was important for tethering DPM1, the catalytic subunit of the enzyme, to the endoplasmic reticulum membrane and, therefore, was critical for enzyme activity (Ashida 2006)
  • HOMOLOGY
    interspecies homolog to C.elegans y56H1A.2
    Homologene
    FAMILY
  • DPM3 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • stabilizator of DPM1 with enzyme activity
  • required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose (Ashida 2006)
  • plays an important role in four different glycosylation routes in the ER (Lefeber 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • association to DPM1 to DPM2 by its C and N terminus respectively (DPM1 was rapidly degraded by the proteasome in the absence of DPM3) (Ashida 2006)
  • cell & other
    REGULATION
    Other regulated by phospholipase C gamma
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1O
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in invasive prostate tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS