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FLASH GENE
Symbol CRTAC1 contributors: npt/mct - updated : 19-09-2012
HGNC name cartilage acidic protein 1
HGNC id 14882
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leader peptide
  • hydrophobic AA sequences corresponding to a primary transmembrane helix of 627 to 646 AAs
  • four phenylalanyl–glycyl and glycyl–alanyl–prolyl (FG-GAP) domains
  • C terminal EGF-like calcium-binding domain encoding sequence, (UA/EC domain) bound to RTN4R, and blocks the binding of RTN4 to RTN4R
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • glycosylated extracellular matrix molecule of articular cartilage
  • functions in lateral olfactory tract development through an antagonism to RTN4R
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to RTN4R and functions as an endogenous RTN4R antagonist
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    UA/EC domain may be useful for therapeutic approaches in injured or degenerative brains
    ANIMAL & CELL MODELS