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FLASH GENE
Symbol CRTAC1 contributors: npt/mct - updated : 19-09-2012
HGNC name cartilage acidic protein 1
HGNC id 14882
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Respiratorylung    
Urinarykidney   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leader peptide
  • hydrophobic AA sequences corresponding to a primary transmembrane helix of 627 to 646 AAs
  • four phenylalanyl–glycyl and glycyl–alanyl–prolyl (FG-GAP) domains
  • C terminal EGF-like calcium-binding domain encoding sequence, (UA/EC domain) bound to RTN4R, and blocks the binding of RTN4 to RTN4R
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • glycosylated extracellular matrix molecule of articular cartilage
  • functions in lateral olfactory tract development through an antagonism to RTN4R
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to RTN4R and functions as an endogenous RTN4R antagonist
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    UA/EC domain may be useful for therapeutic approaches in injured or degenerative brains
    ANIMAL & CELL MODELS