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FLASH GENE
Symbol FUSE contributors: mct - updated : 05-01-2021
HGNC name polykaryocytosis promoter
HGNC id 4011
Location 10      Physical location : -
Synonym name c-myc far-upstream element
DNA
TYPE like-sequence
SPECIAL FEATURE
text
  • cis element located more than 1500 bp upstream of the c-myc gene, involved in c-myc transcriptional regulation
  • melts into single-stranded DNA upon active transcription, and the noncoding strand FUSE recruits an activator (the FUSE-binding protein (FUBP1)) and a repressor (the FBP-interacting repressor (PUF60)) to fine-tune c-myc transcription
  • motif
    text structure
  • conformational differences between the coding and noncoding FUSE suggest that upon FUSE melting, the coding strand becomes compact while the noncoding strand remains extended and linear, making its sequence freely available for the DNA-protein interactions required in the process
  • contains an A/T-rich sequence
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 31.4 - - - 20420426
    also called FUSE31
    - - - - 14.9 - - 20420426
    alsos called FUSE14
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FUSEA/FUBP1/PUF60 complex
  • FUBP1-FUSE complex is an essential component of a transcription molecular machinery that is necessary for tight regulation of expression of many key genes including MYC and CDKN1A
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to PUF60, as well as to the central domain of FUBP1, and forms a stable tripartite FUSE-FUBP1-PUF60 complex, which represses activated but not basal c-myc transcription after transcription initiation by delaying promoter escape
  • FUBP1 utilizes its four articulated KH modules, which function cooperatively, for FUSE nucleotide binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS