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FLASH GENE
Symbol KCNK10 contributors: mct - updated : 22-10-2014
HGNC name potassium channel, subfamily K, member 10
HGNC id 6273
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments
  • two pore-forming domains arranged in a tandem outward rectifier channel
    • conjugated GlycoP
    HOMOLOGY
    interspecies Drosophilia Ir
    homolog to C.elegans irk-2
    intraspecies homolog to TREK1
    Homologene
    FAMILY
  • two-pore domain (K2P) superfamily
  • potassium channel, subfamily K
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • target of neurotransmitter action
  • exhibits two primary modes of gating that give rise to two channel phenotypes under dephosphorylated conditions, and its phosphorylation shifts the gating mode to include intermediate conducting levels
  • KCNK2, KCNK10 are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • potassium channel
  • passive transporter
    • PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    zinc activated
    protein
  • neurotransmitter receptors
  • KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
  • hyperpolarizes IB4 binding C-nociceptors and limits pathological spontaneous pain
    • cell & other
    REGULATION
    activated by polyinsaturated fatty acids lysophospholipids,anesthetic chloroform,halothane,riluzole
    Gs,Gi,Gy protein coupled receptors
    arachidonic acid,membrane stretching,intracellular acidification
    Other mechadosensitive channel
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS