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FLASH GENE
Symbol SLCO1B3 contributors: mct/npt - updated : 07-10-2019
HGNC name solute carrier organic anion transporter family, member 1B3
HGNC id 10961
Location 12p12      Physical location : 20.963.637 - 21.069.656
Synonym name
  • solute carrier family 21 (organic anion transporter), member 8
  • liver-specific organic anion transporter 3TM13
  • organic anion transporter LST-3c
    • Synonym symbol(s) OATP8, SLC21A8, LST-3TM13, OATP1B3, LST2
    DNA
    TYPE functioning gene
    STRUCTURE 106.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2712 77.4 702 - Kiyotani (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Kazal type, serine protease inhibitor domain
  • twelve transmembrane domain
  • N glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SLC21A superfamily of solute carriers
  • organo anion transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • transporter in the membrane of sulfobromophtalein and 17 beta glucocoronosyl estradiol
  • transporter of exogenous substrates : digoxin anionic cyclic peptides
  • functioning as bidirectional facilitated diffusion transporters but GSH is not a substrate or activator of their transport activity
  • may mediate the extrusion of organic anions by symporting with glutathione as a normal route of exporting metabolites produced by hepatocytes or preventing their intracellular accumulation when their vectorial traffic toward the bile is impaired
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS extracellular transport , active transport
    text organic anion transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    SLCO1B3, SLCO2A1, SLC33A1 and SLCO4A1 are up-regulated in pancreatic adenocarcinoma (
    Susceptibility to risk of leukopenia/neutropenia induced by docetaxel chemotherapy
    Variant & Polymorphism SNP SNPs that may predict the risk of leukopenia/neutropenia induced by docetaxel chemotherapy
    Candidate gene
    Marker
  • is a potential marker to diagnose patients with early stage pancreatic adenocarcinomas
    • Therapy target
    ANIMAL & CELL MODELS