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| Nte(-/-) mice die after embryonic day 8, and Nte(+/-) mice have lower activity of Nte in the brain and higher mortality when exposed to the Nte-inhibiting compound ethyl octylphosphonofluoridate  | |
Heterozygous NTE(+/-) mice displayed a 50% reduction in NTE activity but underwent normal organ development while NTE(-/-) mice died at embryonic day 9 postcoitum |
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PNPLA6 insufficiency using morpholino oligonucleotide knockdown in zebrafish results in developmental abnormalities and motor neuron defects including axon truncation and branching |