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FLASH GENE

Symbol

PGDS

contributors: mct/npt - updated : 01/10/2008

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	44.32 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 1615 23 199 - Inoue (2004)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pharynx         Reproductive female system placenta         male system male genital tract         male system prostate

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

prominent cleft as the active site, which is never seen among other members of GST family

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

sigma class glutathione S transferase/lipocalin family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

plays a role in the production of prostanoids in the immune system and mast cells

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

text	differentiation of megakaryocytes

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

phorbol esters in megakaryocytes

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS