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FLASH GENE
Symbol PGDS contributors: mct/npt - updated : 01/10/2008
Location 4q22.3      Physical location : -
Genatlas name prostaglandin D2 synthase, hematopoietic
Synonym name
  • hematopoietic prostaglandin D2 synthase
  • glutathione-requiring prostaglandin D synthase
  • glutathione-dependent PGD synthetase
    • Synonym symbol(s) H-PGDS
    EC.number 5.3.99.2
    DNA
    TYPE functioning gene
    STRUCTURE 44.32 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1615 23 199 - Inoue (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx    
    Reproductivefemale systemplacenta   
     male systemmale genital tract   
     male systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prominent cleft as the active site, which is never seen among other members of GST family
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • sigma class glutathione S transferase/lipocalin family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • plays a role in the production of prostanoids in the immune system and mast cells
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of megakaryocytes
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by phorbol esters in megakaryocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS