basic FUNCTION
| participating in the internalization of the LDL-LDLR complex, possibly enhancing the efficiency of the packaging into endocytic vesicles |
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required for the efficient activity of low density lipoprotein receptor (LDLR) in selected tissues |
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appears to have a tissue-specific role in LDLR function, as it is required in liver but not in fibroblasts |
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endocytic sorting adaptor that actively participates in the internalization of the LDL-LDLR complex, possibly enhancing the efficiency of its packaging into the endocytic vesicles |
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in addition to its role in endocytosis, cooperates with AP-1B in basolateral exocytosis of LDLR from recycling endosomes (REs) |
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combination of LDLRAP1 and DAB2 is responsible for the majority of adaptor function in LDLR endocytosis and LDLR-mediated cholesterol homeostasis |