Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCNE3 contributors: mct/npt - updated : 20-09-2007
HGNC name potassium voltage-gated channel, Isk-related family, member 3
HGNC id 6243
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single transmembrane segment
    • conjugated GlycoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kcne3 (92.23 pc)
    homolog to murine Kcne3 (93.20 pc)
    intraspecies homolog to KCNE1
    Homologene
    FAMILY
  • potassium channel KCNE family
  • Isk related (IRK) subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • modulating the gating kinetics
  • enhancing stability of the multimeric complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text voltage-gated potassium channel complex
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramers KCNQ1/KCNE3, KCNC4/KCNE3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the pore forming channel KCNC4 (kv3.4) and restituting its native attributes in muscle
  • KCNQ1
  • the pore forming channel KCNQ1 to form the potassium channel that is important for intestinal chloride secretion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HOKPP3 , THYPOKPP , LQT10 , BRGS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS