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FLASH GENE
Symbol KCNE3 contributors: mct/npt - updated : 20-09-2007
HGNC name potassium voltage-gated channel, Isk-related family, member 3
HGNC id 6243
Corresponding disease
BRGS6 Brugada syndrome 6
HOKPP3 hypokalemic periodic paralysis
LQT10 long QT syndrome with ventricular tachyarrhythmia, type 10
THYPOKPP thyrotoxic hypokalemic paralysis
Location 11q13.4      Physical location : 74.165.887 - 74.178.600
Synonym name
  • mink-related peptide 2
  • minimum potassium ion channel-related peptide 2
  • cardiac voltage-gated potassium channel accessory subunit
  • voltage-gated K+ channel subunit MIRP2
  • Synonym symbol(s) MIRP2, HOKPP, DKFZp781H21101, MGC102685, MGC129924
    DNA
    TYPE functioning gene
    STRUCTURE 12.71 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure binding sites for SP1, ETS, GABP, NFAT, NRF2
    MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ00012 11q13.3 hypothetical protein FLJ00012 KIAA0769 11q13.2 hypothetical protein FLJ00012 P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 639 - 99 kidney, liver, prostate, spleen, ovary, placenta, leukocytes Lundquist
  • also called KCNE3a
  • - - 515 - 99 kidney, liver, prostate, spleen, ovary, placenta, leukocytes Lundquist
  • also called KCNE3b
  • 3 - 3070 11.71 103 - Lundquist
    also called KCNE3m
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestinejejunumcrypt of Lieberkuhn 
     intestinelarge intestinecolon moderately
     salivary gland   highly
    Lymphoid/Immunespleen   lowly
    Reproductivefemale systemplacenta  lowly
     female systemovary  lowly
     male systemprostate  lowly
    Respiratorylung   lowly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single transmembrane segment
  • conjugated GlycoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kcne3 (92.23 pc)
    homolog to murine Kcne3 (93.20 pc)
    intraspecies homolog to KCNE1
    Homologene
    FAMILY
  • potassium channel KCNE family
  • Isk related (IRK) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • modulating the gating kinetics
  • enhancing stability of the multimeric complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text voltage-gated potassium channel complex
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramers KCNQ1/KCNE3, KCNC4/KCNE3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the pore forming channel KCNC4 (kv3.4) and restituting its native attributes in muscle
  • KCNQ1
  • the pore forming channel KCNQ1 to form the potassium channel that is important for intestinal chloride secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HOKPP3 , THYPOKPP , LQT10 , BRGS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS