| basic FUNCTION
| SNARE regulatory protein, regulating positively a late step in synaptic vesicle exocytosis |
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also involved in glucose-induced secretion of insulin by pancreatic beta-cells |
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playing a necessary role for the acrosome reaction in sperm  |
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presynaptic protein that modulate neurotransmitter release and are used as markers of inhibitory synapses |
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is required for faithful processing of sound onset and offset in the cochlear nucleus |
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organizes the SNAREs into a zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion |
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with SYT1, CPLX1 synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations |
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is a small, SNARE-associated protein believed to regulate fast, calcium-triggered exocytosis |
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role of CPLX1 and CPLX2 in facilitating vesicle priming, suggesting that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels |
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because both SNCA and CPLX1 modulate vesicle release, likely presynaptic dysfunction is an early event in Parkinson disease pathology |
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CPLX1 utilizes distinct mechanisms for synchronization of Ca(2+)-triggered fusion and inhibition of spontaneous fusion |
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small synaptic protein that cooperate with SNARE-complexes in the control of synaptic vesicle (SV) fusion |
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presynaptic proteins CPLX1 and CPLX2 differentially influence cognitive function in early and late stages of Alzheimer disease |
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CPLX1 generates a focused clamp for the neuronal SNARE complex in a linker-open conformation |
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