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FLASH GENE

Symbol

FSHB

contributors: mct - updated : 11-10-2022

HGNC name	follicle stimulating hormone, beta polypeptide
HGNC id	3964

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HH24

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function associated with azoospermia or suppressed spermatogenesis (

Susceptibility

to azoo-oligozoospermia

Variant & Polymorphism SNP	FSHB-211 TT genotype was associated with significantly lower FSH levels, and seen in 25p100 of subjects with azoo-oligozoospermia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

male mice feeding a short-term HFD induces Fshb synthesis and Ffar4 expression in their pituitary gonadotropes