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FLASH GENE
Symbol FSHB contributors: mct - updated : 11-10-2022
HGNC name follicle stimulating hormone, beta polypeptide
HGNC id 3964
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer heteromer , dimer
HOMOLOGY
interspecies ortholog to rattus Fshb
ortholog to murine Fshb
Homologene
FAMILY
  • glycoprotein hormones beta chain family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text
  • soluble fraction
    • basic FUNCTION
  • stimulating development of follicle and spermatogenesis in the reproductive organs
  • playing a crucial role in the regulation of fertility
  • conservative vertebrate gene with a unique function and it is located in a structurally stable gene-poor region
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text
  • ovarian follicle development
  • spermatogenesis
  • pregnancy
    • PATHWAY
    metabolism
    signaling hormonal
    a component
  • heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FOXL2 (novel role for FOXL2 in activin A-regulated FSHB transcription)
  • expression of BRMS1L depends on CTNNB1 activity and contributes to FSHB induction by GNRH1
  • SMAD4 and FOXL2 are essential master regulators of FSHB transcription
  • SMAD4 and FOXL2 are master transcriptional mediators of activin signaling that act together and independently of GNRH to regulate FSHB gene expression and female fertility
  • FOXL2 and SMAD4 play essential roles in human FSHB expression
  • enhancer is directly targeted by activin signaling and activin and GNRH can regulate FSHB transcription
    • cell & other
    REGULATION
    activated by LHX3 LIM homeodomain transcription factor in the pituitary gonadotrope cell
    induced by Activin A, though weak on its own, synergized with GNRH1 to stimulate human FSHB promoter activity
    Other production of gonadotropin FSHB is modulated by positive transcription factors and negative corepressors with different pulse sensitivities
    SMAD4 participates in complexes with SMAD2 and SMAD3 to regulate FSHB expression
    testosterone regulates FSHB transcription, in part, through modulation of various components of the activin-signaling system
    ASSOCIATED DISORDERS
    corresponding disease(s) HH24
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    associated with azoospermia or suppressed spermatogenesis (
    Susceptibility to azoo-oligozoospermia
    Variant & Polymorphism SNP
  • FSHB-211 TT genotype was associated with significantly lower FSH levels, and seen in 25p100 of subjects with azoo-oligozoospermia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • male mice feeding a short-term HFD induces Fshb synthesis and Ffar4 expression in their pituitary gonadotropes