Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

FSHB

contributors: mct - updated : 11-10-2022

HGNC name	follicle stimulating hormone, beta polypeptide
HGNC id	3964

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000510 3 splicing 1936 NP_000501 - 129 - 2021 33009549 NM_001018080 3 splicing 1906 NP_001018090 - 129 - 2021 33009549 NM_001382289 3 - 1856 NP_001369218 - 129 - 2021 33009549

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to rattus Fshb
	ortholog to murine Fshb

Homologene

FAMILY

glycoprotein hormones beta chain family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
text	soluble fraction

basic FUNCTION	stimulating development of follicle and spermatogenesis in the reproductive organs
	playing a crucial role in the regulation of fertility
	conservative vertebrate gene with a unique function and it is located in a structurally stable gene-poor region

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , reproduction/sex

text	ovarian follicle development
	spermatogenesis
	pregnancy

PATHWAY

metabolism

signaling

hormonal

a component

heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin

INTERACTION

DNA

RNA

small molecule

protein	interacting with FOXL2 (novel role for FOXL2 in activin A-regulated FSHB transcription)
	expression of BRMS1L depends on CTNNB1 activity and contributes to FSHB induction by GNRH1
	SMAD4 and FOXL2 are essential master regulators of FSHB transcription
	SMAD4 and FOXL2 are master transcriptional mediators of activin signaling that act together and independently of GNRH to regulate FSHB gene expression and female fertility
	FOXL2 and SMAD4 play essential roles in human FSHB expression
	enhancer is directly targeted by activin signaling and activin and GNRH can regulate FSHB transcription

cell & other

REGULATION

activated by

LHX3 LIM homeodomain transcription factor in the pituitary gonadotrope cell

induced by	Activin A, though weak on its own, synergized with GNRH1 to stimulate human FSHB promoter activity

Other	production of gonadotropin FSHB is modulated by positive transcription factors and negative corepressors with different pulse sensitivities
	SMAD4 participates in complexes with SMAD2 and SMAD3 to regulate FSHB expression
	testosterone regulates FSHB transcription, in part, through modulation of various components of the activin-signaling system

ASSOCIATED DISORDERS

corresponding disease(s)

HH24

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function associated with azoospermia or suppressed spermatogenesis (

Susceptibility

to azoo-oligozoospermia

Variant & Polymorphism SNP	FSHB-211 TT genotype was associated with significantly lower FSH levels, and seen in 25p100 of subjects with azoo-oligozoospermia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

male mice feeding a short-term HFD induces Fshb synthesis and Ffar4 expression in their pituitary gonadotropes