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FLASH GENE
Symbol ATP6V1C1 contributors: mct/npt - updated : 06-04-2010
HGNC name ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
HGNC id 856
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 5704 - 382 - Van Hille (1993)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
HOMOLOGY
interspecies homolog to murine Atp6v1c1 (97.4pc)
homolog to rattus Atp6v1c1 (97.9pc)
Homologene
FAMILY
  • V-ATPase C subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • colocalized with F-actin in the cytoplasm
  • localized on the ruffled border of activated osteoclasts
    • basic FUNCTION
  • ATPase synthase H+ transporting, catalytic subunit of the peripheral V1 complex of the vacuolar proton pump
  • regulating ATP binding and hydrolysis by the A and B subunits
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regualte F-actin ring formation in osteoclast differentiation (Feng 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the heteromultimeric complex composed of a peripheral catalytic V1 complex attached to an integral V0 membrane pore complex
  • component of a complex with ATP6D, ATP6E binding to the hexamer ATP6A/ATP6B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATP6V0A3
    • cell & other
    REGULATION
    induced by TNFSF11 during osteoclast differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS