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FLASH GENE
Symbol ATP6V1C1 contributors: mct/npt - updated : 06-04-2010
HGNC name ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
HGNC id 856
Location 8q22.3      Physical location : 104.033.247 - 104.085.284
Synonym name
  • H+-transporting ATPase chain C, vacuolar
  • vacuolar proton-ATPase, subunit C, VI domain
  • subunit C of vacuolar proton-ATPase V1 domain
  • H(+)-transporting two-sector ATPase, subunit C
  • ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1
  • V-type proton ATPase subunit C 1
    • Synonym symbol(s) ATP6D, ATP6C, VATC, Vma5, FLJ20057, ATP6C
    EC.number 3.6.3.14
    DNA
    TYPE functioning gene
    STRUCTURE 52.04 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure GC boxes and E-boxes in the promoter (Izumi 2003)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5704 - 382 - Van Hille (1993)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated Other
    HOMOLOGY
    interspecies homolog to murine Atp6v1c1 (97.4pc)
    homolog to rattus Atp6v1c1 (97.9pc)
    Homologene
    FAMILY
  • V-ATPase C subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • colocalized with F-actin in the cytoplasm
  • localized on the ruffled border of activated osteoclasts
    • basic FUNCTION
  • ATPase synthase H+ transporting, catalytic subunit of the peripheral V1 complex of the vacuolar proton pump
  • regulating ATP binding and hydrolysis by the A and B subunits
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles (Pietrement 2006)
  • essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regualte F-actin ring formation in osteoclast differentiation (Feng 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport , electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the heteromultimeric complex composed of a peripheral catalytic V1 complex attached to an integral V0 membrane pore complex
  • component of a complex with ATP6D, ATP6E binding to the hexamer ATP6A/ATP6B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATP6V0A3
    • cell & other
    REGULATION
    induced by TNFSF11 during osteoclast differentiation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS