Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

BNIP3

contributors: mct/pgu - updated : 15-06-2015

HGNC name	BCL2/adenovirus E1B 19kDa interacting protein 3
HGNC id	1084

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by aberrant DNA methylation of the 5' CpG island and histone deacetylation in haematopoietic tumours tumoral     --low   in chronic pancreatitis and pancreatic cancer with poorer survival tumoral     --low   downregulated in primary myelofibrosis constitutional     --over   in heart failure and contributes to loss of myocardial cells during I/R (ischaemia/reperfusion) constitutional     --low   was protective against hypoxia-induced autophagy and cell death

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   . FOXO3 and BNIP3 as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved cancer     . FOXO3 and BNIP3 as potential therapeutic targets in muscle wasting disorders and other degenerative and neoplastic diseases in which autophagy is involved cancer     treatment with Torin1, an MTOR inhibitor, decreased the BNIP3 level and enhanced the death of hypoxic tumor cells

ANIMAL & CELL MODELS