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FLASH GENE

Symbol

CKB

contributors: mct - updated : 15-04-2015

HGNC name	creatine kinase, brain
HGNC id	1991

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.20 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

N

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001823 8 - 1475 NP_001814 - 381 - Wang (2006)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system prostate     highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Ckb

Homologene

FAMILY

guanido phosphotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in energy homeostasis
	reversibly catalyzing the transfer of phosphate between ATP and various phosphogens such as creatine phosphate
	playing a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa
	playing an important role in the bone-resorbing function of osteoclasts
	regulates mature osteoclast activity, including the formation and maintenance of the actin sealing ring and the activities of V-ATPase and RhoA
	contribute to osteoclast function
	downregulation of CKB may play an important role in colon cancer progression by promoting EMT
	AMPK and CKB cooperate under energy stress to compensate for loss of adenosine triphosphate (ATP) by either stimulating ATP-generating and inhibiting ATP-consuming pathways
	localized CKB plays a key role in myotube formation by limiting myoblast fusion during myogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic

signaling

a component

homodimerizing or heterodimerizing with CKM

INTERACTION

DNA

RNA

small molecule

protein	CKB interacts with ASB9 in a specific, SOCS box-independent manner
	HPCA specifically bound to CKB in a Ca(2+)-dependent manner, but not to the muscle-type CKM subunit
	ASB9 binds to creatine kinase (CKB) and targets it for degradation

cell & other

REGULATION

induced by	in mature osteoclasts, and by TNFSF11 during osteoclastogenesis

repressed by

PARP1 (activity of PARP1 was determined to be required for its inhibitory effect on the CKB expression)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   during osteoclastogenesis tumoral     --low   in colon cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS