Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LTB4R2

contributors: mct - updated : 26-08-2013

HGNC name	leukotriene B4 receptor 2
HGNC id	19260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven membrane spanning domain (7TM)

HOMOLOGY

intraspecies

homolog to BLT

Homologene

FAMILY

rhodopsin family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	chemotactic mediator for inflammation
	potent activator and chemoattractant for leukocytes and is implicated in several inflammatory diseases
	plays an essential role in mediating VEGF-induced angiogenesis
	unique receptor for 5-lipoxygenase- and cyclooxygenase-1-derived lipid mediators, and is a novel target for therapies directed at treating inflammation associated with arthritis
	involved in multiple cellular responses, including chemotaxis
	key regulator of AR expression and will contribute to the development of novel therapies for AR-positive prostate cancers, including androgen-responsive and castration-resistant prostate cancers

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

LTB(4)-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation

a component

INTERACTION

DNA

RNA

small molecule

protein	LTB4
	RANBP9 acts as a negative regulator of LTB4R2

cell & other

REGULATION

Phosphorylated by

AKT1 (AKT1 phosphorylates LTB4R2 at its C-terminal Thr(355) residue and this event is critical for LTB4R2-mediated chemotactic responses)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the highly aggressive human breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer urinary   potential target for anti-bladder cancer therapy

ANIMAL & CELL MODELS