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FLASH GENE

Symbol

LTB4R2

contributors: mct - updated : 26-08-2013

HGNC name	leukotriene B4 receptor 2
HGNC id	19260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q12      Physical location : 24.779.356 - 24.781.259
Synonym name	seven transmembrane receptor leukotriene B4
	LTB4 receptor JULF2
	leukotriene B4 receptor BLT2
	seven transmembrane receptor BLTR2
Synonym symbol(s)	BLT2, JULF2, BLTR2, LTB4-R2, NOP9

DNA

TYPE	functioning gene
STRUCTURE	1.90 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	intronless
	embedded in the promoter region of LTB4R

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014430 1 - 2252 NP_055245 - 219 - - NM_001164692 2 - 1560 NP_001158164 - 358 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular vessel         Homo sapiens Digestive intestine small intestine       Endocrine neuroendocrine pituitary         pancreas         Lymphoid/Immune thymus         Reproductive female system ovary         male system testis       Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Cardiovascular endothelial cell Homo sapiens Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven membrane spanning domain (7TM)

HOMOLOGY

intraspecies

homolog to BLT

Homologene

FAMILY

rhodopsin family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	chemotactic mediator for inflammation
	potent activator and chemoattractant for leukocytes and is implicated in several inflammatory diseases
	plays an essential role in mediating VEGF-induced angiogenesis
	unique receptor for 5-lipoxygenase- and cyclooxygenase-1-derived lipid mediators, and is a novel target for therapies directed at treating inflammation associated with arthritis
	involved in multiple cellular responses, including chemotaxis
	key regulator of AR expression and will contribute to the development of novel therapies for AR-positive prostate cancers, including androgen-responsive and castration-resistant prostate cancers

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

LTB(4)-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation

a component

INTERACTION

DNA

RNA

small molecule

protein	LTB4
	RANBP9 acts as a negative regulator of LTB4R2

cell & other

REGULATION

Phosphorylated by

AKT1 (AKT1 phosphorylates LTB4R2 at its C-terminal Thr(355) residue and this event is critical for LTB4R2-mediated chemotactic responses)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the highly aggressive human breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer urinary   potential target for anti-bladder cancer therapy

ANIMAL & CELL MODELS