| basic FUNCTION
| cell adhesion |
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inflammation apoptosis and metastasis |
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T cell derived regulator of eosinophil recruitment in tissues during inflammatory reactions |
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eosinophil chemoattractant |
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induces osteoblast differentiation through the CD44/Smad signaling in the absence of BMPs (Tanikawa 2010) |
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increases alkaline phosphatase activities in osteoblasts and induces the phosphorylation of Smad1/5/8 and translocation of Smad4 tot he nucleus in the absence of BMPs (Tanikawa 2010) |
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also inducing binding of smad4 to the Id1 promoter and increases its activity (Tanikawa 2010) |
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involved in modulating cell-cell and cell-matrix interactions |
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might participate in the interaction between the hormone and receptor cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency |
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may play a role in thymocyte-eptihelial interactions relevant to the biology of the thymus |
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inhibits cell proliferation |
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inducing Th1 death |
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ligand for HAVCR2/TIM3 |
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inducing proliferation of osteoblasts through clustering lipid rafts on membrane and subsequent phosphorylation of the c-Src/ERK signaling pathway (Tanikawa 2008) |
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autocrine regulator of mast cell function to suppress excessive degranulation (niki 2009) |
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may have an immunoregulatory function during the ongoing cytotoxic response during a rejection episode (Naka 2009) |
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LPS-responsive factor that transactivates inflammatory cytokines gene in monocytes through direct interaction with CEBPB (Matsuura 2009) |
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regulates T helper cell function independently of HAVCR2  |
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suppresses Th17 cell development in an IL2-dependent but HAVCR2-independent manner |
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LGALS9/HAVCR2 interactions inducing resistance of activated CD4(+) T cells to HIV-1 infection which suggest that LGALS9 may play a role in HIV-1 pathogenesis |
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LGALS9 engagement impairs the function of NK cells, including cytotoxicity and cytokine production |
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contributes to the inducible immunomodulatory functions of mesenchymal stromal cells (MSCs) |
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has likely dual properties as both a regulator and an activator of mast cells |
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exogenous LGALS9, in addition to being an effector molecule for Treg cells, acts synergistically with TGFB1 to enforce nduced regulatory T cells (iTreg) differentiation and maintenance |
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activation of CNS LGALS9 likely modulates neuroinflammatory processes in which TNF and IL6 contribute to either pathology or reparation |
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tandem repeat type of galectin, was originally identified as a chemotactic factor for eosinophils, and is also involved in the regulatory process of inflammation |
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possible involvement of the HAVCR2/LGALS9 system in the modulation of inflammatory bone destruction |
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LGALS9 is enriched in lysosomes and predominantly binds to lysosome-associated membrane protein 2 (LAMP2) in a Asn(N)-glycan dependent manner |
