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FLASH GENE

Symbol

GSTO1

contributors: mct - updated : 09-09-2011

HGNC name	glutathione S-transferase omega 1
HGNC id	13312

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   appears to be associated with activation of survival pathways (Akt and ERK1/2) and inhibition of apoptotic pathways (JNK1), as well as protection against cisplatin-induced apoptosis

Susceptibility

to variation of the age at onset of Alzheimer disease to hepatocellular carcinoma, cholangiocarcinoma and breast cancer

Variant & Polymorphism insertion/deletion	polymorphic deletion of Glu-155 causes a deficiency of GSTO1 (by its low stability, resulting from its increased propensity to unfold), may contribute to the observed association of GSTO1 with the age at onset of Alzheimer disease
	GSTO1*A140D polymorphism could play an important role as a risk factor for the development ofhepatocellular carcinoma, cholangiocarcinoma and breast cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS