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FLASH GENE

Symbol

GSTO1

contributors: mct - updated : 09-09-2011

HGNC name	glutathione S-transferase omega 1
HGNC id	13312

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.33      Physical location : 106.013.951 - 106.027.220
Synonym name	glutathione-S-transferase like
	glutathione transferase omega
	GSTO 1-1
Synonym symbol(s)	GSTTLP28, P28, DKFZp686H13163
EC.number	1.20.4.2 / 1.8.5.1

DNA

TYPE	functioning gene
STRUCTURE	12.54 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004832 6 - 1017 27.4 241 widely expressed in many tissues 2000 10783391 capable of playing a major role in the glutathionylation cycle NM_001191003 6 - 1070 - 213 - 2000 10783391 NM_001191002 5 - 918 - 208 - 2000 10783391

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Nervous brain       lowly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal 19-20AA extension
	thioredoxin-like domains
	a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
	an active site cysteine residue that is essential for its primary catalytic activities
	seven alpha helices abriting the C terminal

mono polymer

monomer

HOMOLOGY

interspecies

homolog to murine P28

intraspecies

homolog to GSTO2

Homologene

FAMILY

cytosolic glutathione transferase super family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	small stress response protein likely involved in cellular redox homeostasis
	implicated in the post-translational processing and activation of the proinflammatory mediator interleukin-1B
	inhibitor of cardiac muscle ryanodine receptor Ca2+ channels
	nuclear translocation could be potentially involved in the stress response of human cells playing a role in the cancer progression of Barrett esophagus
	two isozymes (GSTO1 and GSTO2) have significant DHA reductase (DHAR) activity
	participates in the glutathionylation cycle and targets specific proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   appears to be associated with activation of survival pathways (Akt and ERK1/2) and inhibition of apoptotic pathways (JNK1), as well as protection against cisplatin-induced apoptosis

Susceptibility

to variation of the age at onset of Alzheimer disease to hepatocellular carcinoma, cholangiocarcinoma and breast cancer

Variant & Polymorphism insertion/deletion	polymorphic deletion of Glu-155 causes a deficiency of GSTO1 (by its low stability, resulting from its increased propensity to unfold), may contribute to the observed association of GSTO1 with the age at onset of Alzheimer disease
	GSTO1*A140D polymorphism could play an important role as a risk factor for the development ofhepatocellular carcinoma, cholangiocarcinoma and breast cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS