Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALS2CR2 contributors: - updated : 04-12-2006
HGNC name amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
HGNC id 13205
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal ATP-binding site
  • serine/threonine kinase catalytic domain
  • C terminal phosphorylation sites
    • HOMOLOGY
    interspecies homolog to chimpanzee ALS2CR2 (95.9 pc)
    homolog to murine Als2cr2 (90.9 pc)
    homolog to chicken ALS2CR2 (74.9 pc)
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • STE20 subfamily
  • Ste20/germinal center kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • potentiating the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 and other JNK family members
  • activates and relocating STK11 from the nucleus to the cytoplasm
  • playing an essential role in STK11-mediated G1 cell cycle arrest
    • CELLULAR PROCESS cell cycle
    cell life, antiapoptosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • coexisting in a complex with TAK1, TRAF6, TAB1 and TAB2
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • interacting with XIAP
  • binding to STK11
  • complexing with CAB39
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS