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FLASH GENE

Symbol

ALS2CR2

contributors: - updated : 04-12-2006

HGNC name	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
HGNC id	13205

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
STRUCTURE	29.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D2S116 - BZW1 - CLK1 - NIF3L1 - ORC2L - D2S309 - CFLAR - CASP10 - CASP8 - TRAK2 /ALS2CR2 - D2S2309 - D2S2214 - D2S346 - SUMO1 - BMPR2 - D2S2289 - ABI2 - CD28 - CTLA4 - D2S723 - D2S105 - D2S2189 - D2S1384 - D2S2237 - qter
Authors	Hadano (01)

regionally located

. close to or overlapping the promoter for ALS2CR3, which is transcribed in the opposite orientation

RNA

TRANSCRIPTS	type	messenger

text	two spliced forms PAPK-A and PAPK-B (Nishigaki, 2003)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       intestine small intestine     highly   liver         Endocrine adrenal gland       moderately   parathyroid       moderately   thyroid       highly Lymphoid/Immune spleen       moderately   thymus       moderately Nervous brain         Reproductive male system testis     moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective adipose     highly Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal ATP-binding site
	serine/threonine kinase catalytic domain
	C terminal phosphorylation sites

HOMOLOGY

interspecies	homolog to chimpanzee ALS2CR2 (95.9 pc)
	homolog to murine Als2cr2 (90.9 pc)
	homolog to chicken ALS2CR2 (74.9 pc)

Homologene

FAMILY	Ser/Thr protein kinase family
	STE20 subfamily
	Ste20/germinal center kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	potentiating the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 and other JNK family members
	activates and relocating STK11 from the nucleus to the cytoplasm
	playing an essential role in STK11-mediated G1 cell cycle arrest

CELLULAR PROCESS	cell cycle
	cell life, antiapoptosis
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

coexisting in a complex with TAK1, TRAF6, TAB1 and TAB2

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	interacting with XIAP
	binding to STK11
	complexing with CAB39

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS