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FLASH GENE

Symbol

POLR2K

contributors: npt/ - updated : 28-11-2007

HGNC name	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
HGNC id	9198

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q22.2      Physical location : 101.162.838 - 101.166.229
Synonym name	DNA directed RNA polymerase II polypeptide K
	RNA polymerases I, II, and III subunit ABC4
Synonym symbol(s)	RPB7.0, RPB10A, RPB12, RPCX, RPABC4, RPB10alpha
EC.number	2.7.7.6

DNA

TYPE	functioning gene
STRUCTURE	3.39 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed POLR2K 4 - 971 6.9 58 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine thyroid         Nervous brain         Reproductive male system prostate     highly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	primitive neurectoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

highly conserved sequence in C terminal half with an invariant motif corresponding to a canonical zinc binding domain

HOMOLOGY

interspecies

homolog to Sc10 alpha

Homologene

FAMILY

archaeal rpoP/eukaryotic RPC10 RNA polymerase subunit family

CATEGORY

enzyme , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

subunit of RNA polymerase II and may be of POLRI and POLRIII

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS