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FLASH GENE
Symbol EBAG9 contributors: - updated : 01-03-2006
HGNC name estrogen receptor binding site associated, antigen, 9
HGNC id 3123
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   moderately
Cardiovascularheart    
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
  • breast cancer MCF-7
  • endometral carcinoma
    • fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		coiled-coil domain necessary for the binding to the receptor
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ebag9
    Homologene
    FAMILY
    CATEGORY antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type III transmembrane protein with a Golgi-predominant localization
    basic FUNCTION
  • estrogen-responsive gene inhibiting cell growth
  • may be playing a role in endocrine-immune interactions in breast cancer
  • inducing growth arrest and apoptosis on activated immune cells, mediated by a putative death receptor
  • modulating surface expression of tumor-associated, normally cryptic O-linked glycan structures and contributing indirectly to the antigenicity of tumor cells
  • acting as a ligand for a putative receptor on immune cells such as peripheral lymphocytes and natural killer cells
  • may play important roles in epithelial ovarian cancer
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text inhibition of cell growth and apoptotic cell death
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SNAPAP in the control on large dense-core vesicle zxocyosis
    cell & other
    REGULATION
    induced by estrogens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non small cell lung carcinoma with poor prognosis, in squamous cell carcinoma of the oesophagus and in gallbladder cancer and ductal breast cancer in progression with poor prognosis
    tumoral     --over  
    in immune-mediated cholangitis,in primary biliary cirrhosis and in hepatocellular carcinoma with tumour dedifferentiation and increased proliferative activity
    tumoral     --over  
    in uterine endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS