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FLASH GENE

Symbol

EBAG9

contributors: - updated : 01-03-2006

HGNC name	estrogen receptor binding site associated, antigen, 9
HGNC id	3123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	24.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site   HRE
text structure	a palindromic estrogen response element (ERE) in the 5' utr

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see ANGPT1

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       moderately Cardiovascular heart         Digestive liver       moderately Nervous brain       moderately Reproductive female system ovary         male system testis         male system prostate       Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum cardiac     Muscular striatum skeletal

cell lineage
cell lines	breast cancer MCF-7
	endometral carcinoma
fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

coiled-coil domain necessary for the binding to the receptor

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Ebag9

Homologene

FAMILY

CATEGORY

antigen , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type III transmembrane protein with a Golgi-predominant localization

basic FUNCTION	estrogen-responsive gene inhibiting cell growth
	may be playing a role in endocrine-immune interactions in breast cancer
	inducing growth arrest and apoptosis on activated immune cells, mediated by a putative death receptor
	modulating surface expression of tumor-associated, normally cryptic O-linked glycan structures and contributing indirectly to the antigenicity of tumor cells
	acting as a ligand for a putative receptor on immune cells such as peripheral lymphocytes and natural killer cells
	may play important roles in epithelial ovarian cancer

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	inhibition of cell growth and apoptotic cell death

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with SNAPAP in the control on large dense-core vesicle zxocyosis

cell & other

REGULATION

induced by

estrogens

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non small cell lung carcinoma with poor prognosis, in squamous cell carcinoma of the oesophagus and in gallbladder cancer and ductal breast cancer in progression with poor prognosis tumoral     --over   in immune-mediated cholangitis,in primary biliary cirrhosis and in hepatocellular carcinoma with tumour dedifferentiation and increased proliferative activity tumoral     --over   in uterine endometrial cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS