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FLASH GENE
Symbol MAPRE3 contributors: mct - updated : 15-06-2016
HGNC name microtubule-associated protein, RP/EB family, member 3
HGNC id 6892
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one calponin homology domain( CH)
    • HOMOLOGY
    interspecies homolog to
    intraspecies homolog to MAPRE1
    Homologene
    FAMILY
  • RP/EB family
  • MAPRE family
    • CATEGORY motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text localized to the tip of motile cilia in bronchial epithelial cells and affects the formation of centriole-associated rootlet filaments
    basic FUNCTION
  • involved in microtubule polymerization and spindle function
  • dynein light chain acting as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway
  • involved in SATB1-mediated gene repression of BCL2 and having functions independent of the dynein motor
  • MAPRE1 and MAPRE3, but not MAPRE2, promote persistent microtubule growth by suppressing catastrophes
  • is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase
  • MAPRE1 and MAPRE3 have a role in the axon initial segment (AIS) in addition to their MT plus-end tracking protein behavior in other neuronal compartments
  • MAPRE1 and MAPRE3 coordinate a molecular and functional interplay between ANK3 and the AIS MTs that supports the central role of ANK3 in the maintenance of neuronal polarity
  • MAPRE1 and MAPRE3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that MAPRE1 and MAPRE3 promote ciliogenesis by facilitating such trafficking
  • affect biogenesis of cilia by several centrosome-related mechanisms and support the idea that different MAPRE1-MAPRE3 dimer species have distinct functions within cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APC
  • binds to and assembles with the transcription factor SATB1 at nuclear matrix-associated structures (nuclear MAPRE3-SATB1 protein complex is assembled with a DNA element of the matrix attachment region of the BCL2 gene)
  • interaction between drebrin and MAPRE3 is important for the dynamic interaction between F-actin and microtubules that underlies growth-cone formation and neuritogenesis
  • interacting with DLG4 through its SH3 doamain (interaction between DLG4 and MAPRE3 elucidates a function for a novel region of MAPRE3 and provides a new and important mechanism for the regulation of microtubules in determining dendritic morphology)
  • CDH5 outside-in signaling regulates cytosolic Ca2+ homeostasis and MAPRE3 phosphorylation, which are required for assembly of adherens junctions (AJs)
  • TTBK2 with MAPRE1/MAPRE3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration
    • cell & other
    REGULATION
    Phosphorylated by Aurora-A and Aurora-B, that phosphorylate endogenous MAPRE3 at Ser-176, and the phosphorylation triggers disruption of the MAPRE3-SIAH-1 complex, resulting in EB3 stabilization during mitosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS