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FLASH GENE

Symbol

MAPRE3

contributors: mct - updated : 15-06-2016

HGNC name	microtubule-associated protein, RP/EB family, member 3
HGNC id	6892

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	56.56 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

close and proximal to ketohexokinase KHK

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012326 7 - 1880 NP_036458 - 281 - 2001 11161807 EBF3L - variant 1 EBF3S - variant 2 - splicing 1880 isoform 2 - 268 brain, skeletal muscle 2001 11161807 including exon 4a

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly   parathyroid       highly Nervous brain diencephalon hypothalamus     Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	eye, lens, optic nerve, retina, choroid, RPE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one calponin homology domain( CH)

HOMOLOGY

interspecies

homolog to

intraspecies

homolog to MAPRE1

Homologene

FAMILY	RP/EB family
	MAPRE family

CATEGORY

motor/contractile , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus
text	localized to the tip of motile cilia in bronchial epithelial cells and affects the formation of centriole-associated rootlet filaments

basic FUNCTION	involved in microtubule polymerization and spindle function
	dynein light chain acting as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway
	involved in SATB1-mediated gene repression of BCL2 and having functions independent of the dynein motor
	MAPRE1 and MAPRE3, but not MAPRE2, promote persistent microtubule growth by suppressing catastrophes
	is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase
	MAPRE1 and MAPRE3 have a role in the axon initial segment (AIS) in addition to their MT plus-end tracking protein behavior in other neuronal compartments
	MAPRE1 and MAPRE3 coordinate a molecular and functional interplay between ANK3 and the AIS MTs that supports the central role of ANK3 in the maintenance of neuronal polarity
	MAPRE1 and MAPRE3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that MAPRE1 and MAPRE3 promote ciliogenesis by facilitating such trafficking
	affect biogenesis of cilia by several centrosome-related mechanisms and support the idea that different MAPRE1-MAPRE3 dimer species have distinct functions within cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	APC
	binds to and assembles with the transcription factor SATB1 at nuclear matrix-associated structures (nuclear MAPRE3-SATB1 protein complex is assembled with a DNA element of the matrix attachment region of the BCL2 gene)
	interaction between drebrin and MAPRE3 is important for the dynamic interaction between F-actin and microtubules that underlies growth-cone formation and neuritogenesis
	interacting with DLG4 through its SH3 doamain (interaction between DLG4 and MAPRE3 elucidates a function for a novel region of MAPRE3 and provides a new and important mechanism for the regulation of microtubules in determining dendritic morphology)
	CDH5 outside-in signaling regulates cytosolic Ca2+ homeostasis and MAPRE3 phosphorylation, which are required for assembly of adherens junctions (AJs)
	TTBK2 with MAPRE1/MAPRE3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration

cell & other

REGULATION

Phosphorylated by

Aurora-A and Aurora-B, that phosphorylate endogenous MAPRE3 at Ser-176, and the phosphorylation triggers disruption of the MAPRE3-SIAH-1 complex, resulting in EB3 stabilization during mitosis

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS