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FLASH GENE
Symbol SNX9 contributors: mct - updated : 07-11-2017
HGNC name sorting nexin 9
HGNC id 14973
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • N terminal SH3 domains followed by a Phox (pX) homology domains, which is a phosphoinositide binding domain, and are involved in intracellular trafficking
  • a PX-BAR domain (Bin/Amphiphysin/Rvs (BAR) domains), having the capacity to tubulate membranes
  • a C terminal coiled-coil domain
    • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Snx9
    homolog to Drosophila Sh3xp1
    intraspecies paralog to SNX18, SNX33
    Homologene
    FAMILY sorting nexin family
    CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text expressed in the presynaptic compartment of cultured hippocampal neurons, where it binds to dynamin-1 and WASL
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • regulating dynamin assembly and required for efficient clathrin-mediated endocytosis
  • able to deform the plasma membrane, as well as liposomes, into narrow tubules and recruit WASL and dynamin 2 to these tubules via its SH3 domain
  • functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes
  • through its interactions, SNX9 plays an important role in clathrin-mediated endocytosis in non-neuronal cells
  • primarily acting in clathrin-mediated endocytosis at the plasma membrane
  • has the ability to activate the actin regulator WASL in a membrane-dependent manner to coordinate actin polymerization with vesicle release
  • functions in a complex with the GTPase dynamin-2 at clathrin-coated pits, where it provokes fission of vesicles to complete endocytosis
  • SNX18 has a similar role to SNX9 in endocytic trafficking at the plasma membrane
  • SNX18 functions with SNX9 in multiple pathways of endocytosis at the plasma membrane and that they are functionally redundant
  • SNX9, SNX18 and SNX33 are required for progression and completion of mitosis
  • plays an additional non-endocytic role at early mitotic stages
  • SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes
  • SNX9 and clathrin heavy chain (CLTC) each have roles in mitosis during metaphase
  • SNX9 and CLTC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association
  • over-expressing SNX9 mostly induced long tubules
  • intracellular SNX9-mediated trafficking constitutes an important ADAM9 regulatory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • can be dimerized, and binds dynamin at one end and WASL at the other, raising the possibility that it links actin dynamics and synaptic vesicle endocytosis
  • SNX18 and SNX9 can form a heterodimer and colocalize in tubular membrane structures
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic domain of metalloprotease disintegrins ADAM9, ADAM15
  • binds strongly to dynamin and is partly responsible for the recruitment of this GTPase to sites of endocytosis
  • CDC42 associated kinase 2 to regulate the degradation of EGFR
  • interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15
  • targets a number of sequences within the proline-rich regions of synaptojanin (SYNJ1)
  • interacts with dynamin-1 and WASL in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis
  • interactions with aldolase are far more extensive and differ from those of the actin-nucleating factor WAS with aldolase, indicating considerable plasticity in mechanisms that direct the functions of the aldolase as a scaffold protein
  • like SNX9, SNX18 interacts with dynamin and stimulates the basal GTPase activity of dynamin
  • interaction between ADAM9 and the intracellular sorting protein, sorting nexin 9 (SNX9), as well as its close homolog SNX18
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS