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FLASH GENE

Symbol

SNX9

contributors: mct - updated : 07-11-2017

HGNC name	sorting nexin 9
HGNC id	14973

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessels aorta     highly Reproductive male system prostate       Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines	melanoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	N terminal SH3 domains followed by a Phox (pX) homology domains, which is a phosphoinositide binding domain, and are involved in intracellular trafficking
	a PX-BAR domain (Bin/Amphiphysin/Rvs (BAR) domains), having the capacity to tubulate membranes
	a C terminal coiled-coil domain

mono polymer

homomer , heteromer , polymer

HOMOLOGY

interspecies	homolog to murine Snx9
	homolog to Drosophila Sh3xp1

intraspecies

paralog to SNX18, SNX33

Homologene

FAMILY

sorting nexin family

CATEGORY

adaptor , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,vesicle
text	expressed in the presynaptic compartment of cultured hippocampal neurons, where it binds to dynamin-1 and WASL

basic FUNCTION	involved in several stage of intracellular trafficking
	regulating dynamin assembly and required for efficient clathrin-mediated endocytosis
	able to deform the plasma membrane, as well as liposomes, into narrow tubules and recruit WASL and dynamin 2 to these tubules via its SH3 domain
	functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes
	through its interactions, SNX9 plays an important role in clathrin-mediated endocytosis in non-neuronal cells
	primarily acting in clathrin-mediated endocytosis at the plasma membrane
	has the ability to activate the actin regulator WASL in a membrane-dependent manner to coordinate actin polymerization with vesicle release
	functions in a complex with the GTPase dynamin-2 at clathrin-coated pits, where it provokes fission of vesicles to complete endocytosis
	SNX18 has a similar role to SNX9 in endocytic trafficking at the plasma membrane
	SNX18 functions with SNX9 in multiple pathways of endocytosis at the plasma membrane and that they are functionally redundant
	SNX9, SNX18 and SNX33 are required for progression and completion of mitosis
	plays an additional non-endocytic role at early mitotic stages
	SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes
	SNX9 and clathrin heavy chain (CLTC) each have roles in mitosis during metaphase
	SNX9 and CLTC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association
	over-expressing SNX9 mostly induced long tubules
	intracellular SNX9-mediated trafficking constitutes an important ADAM9 regulatory pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	can be dimerized, and binds dynamin at one end and WASL at the other, raising the possibility that it links actin dynamics and synaptic vesicle endocytosis
	SNX18 and SNX9 can form a heterodimer and colocalize in tubular membrane structures

INTERACTION

DNA

RNA

small molecule

protein	cytoplasmic domain of metalloprotease disintegrins ADAM9, ADAM15
	binds strongly to dynamin and is partly responsible for the recruitment of this GTPase to sites of endocytosis
	CDC42 associated kinase 2 to regulate the degradation of EGFR
	interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15
	targets a number of sequences within the proline-rich regions of synaptojanin (SYNJ1)
	interacts with dynamin-1 and WASL in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis
	interactions with aldolase are far more extensive and differ from those of the actin-nucleating factor WAS with aldolase, indicating considerable plasticity in mechanisms that direct the functions of the aldolase as a scaffold protein
	like SNX9, SNX18 interacts with dynamin and stimulates the basal GTPase activity of dynamin
	interaction between ADAM9 and the intracellular sorting protein, sorting nexin 9 (SNX9), as well as its close homolog SNX18

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS