Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SNX6 contributors: mct - updated : 13-06-2013
HGNC name sorting nexin 6
HGNC id 14970
Location 14q13.1      Physical location : 35.030.617 - 35.099.366
Synonym name TRAF4 associated factor 2
Synonym symbol(s) TFAF2, MGC3157, MSTP010
DNA
TYPE functioning gene
STRUCTURE 68.45 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 splicing 3080 - 290 - 2001 11279102
  • containing exon 2a (longer than 2b)
  • lacking exon 1
  • 14 splicing 2975 47.67 418 - 2001 11279102
  • containing exon 2b (shorter than 2a)
  • encoding for the longest product
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     liver   highly
    Endocrineparathyroid   predominantly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
     nervecranial nerve  highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phox (PX) homology domain
  • a Vps5 domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans Y59A8B.22
    homolog to rattus Snx6 (99.51 pc)
    homolog to murine Snx6 (99.51 pc)
    intraspecies homolog to SNX5
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text colocalised with SNX1 and SNX5 on early endosomes
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • inhibiting Na/K-ATPase-suppressive activity of TPT1
  • SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates
  • increases BRMS1-dependent transcriptional repression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    a component component of the retromer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TGFB receptors
  • ACVR2B and others SNX
  • TPT1
  • interaction SNX6-DCTN1 for recruitment of the motor complex to the membrane-associated retromer
  • association of SNX6 with breast cancer metastasis suppressor 1 (BRMS1) protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS