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FLASH GENE

Symbol

PROKR1

contributors: mct/npt - updated : 07-07-2020

HGNC name	prokineticin receptor 1
HGNC id	4524

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   PROK1 and PROKR1 expression is elevated in decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes (Evans 2008)

Susceptibility

to recurrent miscarriage (RM)

Variant & Polymorphism other	PROKR1 (I379V) variant conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness

Candidate gene
Marker
Therapy target	may represent a novel therapeutic target to limit myocardial injury following ischemic events (Urayama 2007)

ANIMAL & CELL MODELS