Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PROKR1 contributors: mct/npt - updated : 07-07-2020
HGNC name prokineticin receptor 1
HGNC id 4524
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments
HOMOLOGY
interspecies homolog to murine Gpr73
Homologene
FAMILY
  • G protein coupled receptor family 1
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • PROKR1 was detected in primary cilia
    • basic FUNCTION
  • involved in G-protein coupled receptor protein signaling pathway
  • (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates the expression of several genes with important roles in endometrial receptivity and implantation.
  • PROKR1, but also PROKR2 might mediate a complementary signalling to the RET/GDNF pathway supporting proliferation/survival and differentiation of precursor cells during enteric nervous system (ENS) development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    PROK1-PROKR1 signalling pathway regulating IL11
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein PROK1-PROKR1 interaction induced inositol phosphate mobilization and sequential phosphorylation of c-Src, epidermal growth factor receptor, and ERK 1/2 (Evans 2008)
  • PROK2-induced the formation of vessel-like structures by aortic endothelial cells expressing only PROKR1, and disorganized the tight junctions in hepatic sinusoidal endothelial cells expressing only PROKR2, confirming the divergent roles of these receptors
  • MRAP2 interacts with and inhibits the trafficking and signaling of the prokineticin receptor 1 (PROKR1)
  • TBX20 is a novel transcription factor regulating angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway in both development and disease
  • PROK1 and PROK2 bind to two highly related G protein-coupled receptors (GPCRs), prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    PROK1 and PROKR1 expression is elevated in decidua during early pregnancy and that PROK1-PROKR1 interaction regulates expression of a host of implantation-related genes (Evans 2008)
    Susceptibility to recurrent miscarriage (RM)
    Variant & Polymorphism other
  • PROKR1 (I379V) variant conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness
    • Candidate gene
    Marker
    Therapy target may represent a novel therapeutic target to limit myocardial injury following ischemic events (Urayama 2007)
    ANIMAL & CELL MODELS