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FLASH GENE
Symbol KCNK4 contributors: mct - updated : 22-10-2014
HGNC name potassium channel, subfamily K, member 4
HGNC id 6279
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2733 - 419 - Lesage,Ozaita
11 exons
- splicing 1696 42.7 393 - Lesage,Ozaita
7 exons
- splicing 1821 42.7 393 - Lesaga
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrainhindbraincerebellum  
 spinal cord    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments
  • two pore forming regions (P domains)
  • two P domains arranged like a tandem of inward rectifier channels
    • HOMOLOGY
    intraspecies homolog to TASK1
    Homologene
    FAMILY
  • two pore domain family of potassium channel family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
    • cell & other
    REGULATION
    activated by arachidonic acid,unsatured fatty acid,neuroprotective drug riluzole
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS