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FLASH GENE

Symbol

KCNK4

contributors: mct - updated : 22-10-2014

HGNC name	potassium channel, subfamily K, member 4
HGNC id	6279

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.71 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KCNK4 v1 (HKT4.1B ) - splicing 2733 - 419 - Lesage,Ozaita 11 exons KCNK4 v2 (HKT4.1A ) - splicing 1696 42.7 393 - Lesage,Ozaita 7 exons KCNK4 v3 - splicing 1821 42.7 393 - Lesaga

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine pancreas         Nervous brain hindbrain cerebellum       spinal cord         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane segments
	two pore forming regions (P domains)
	two P domains arranged like a tandem of inward rectifier channels

HOMOLOGY

intraspecies

homolog to TASK1

Homologene

FAMILY

two pore domain family of potassium channel family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

neurotransmission

synaptic transmission

a component

INTERACTION

DNA

RNA

small molecule

protein

KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression

cell & other

REGULATION

activated by

arachidonic acid,unsatured fatty acid,neuroprotective drug riluzole

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS