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FLASH GENE
Symbol RUSC1 contributors: mct - updated : 09-06-2017
HGNC name RUN and SH3 domain containing 1
HGNC id 17153
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RUN domain at its N-terminus, that can bind H-Ras, a downstream signaling molecule of NTRK1, with high affinity
  • a leucine zipper motif,
  • no catalytic domain
  • one VWFC domain
  • a C-terminal SH3 domain
    • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY Rusc family of proteins
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • putative adapter protein
  • functions as an adapter involved in neuronal vesicular transport including vesicles containing soluble N-ethylmaleimide sensitive factor attachment protein receptors that are essential to exocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUSC1 participates in the NGF-NTRK1 signaling pathway
  • RUSC1 and RUSC2 are novel components of the vertebrate HH pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel IKBKG-interacting protein, RUSC1, an adapter molecule previously shown to be involved in the NGF-pathway via the NTRK1
  • RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS