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FLASH GENE
Symbol RUSC1 contributors: mct - updated : 09-06-2017
HGNC name RUN and SH3 domain containing 1
HGNC id 17153
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain     Homo sapiensFetal
Respiratorylung    
Visualeye     Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
IMPRINTING paternally
text expressed maternally (from maternally inherited transcripts)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RUN domain at its N-terminus, that can bind H-Ras, a downstream signaling molecule of NTRK1, with high affinity
  • a leucine zipper motif,
  • no catalytic domain
  • one VWFC domain
  • a C-terminal SH3 domain
    • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY Rusc family of proteins
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • putative adapter protein
  • functions as an adapter involved in neuronal vesicular transport including vesicles containing soluble N-ethylmaleimide sensitive factor attachment protein receptors that are essential to exocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUSC1 participates in the NGF-NTRK1 signaling pathway
  • RUSC1 and RUSC2 are novel components of the vertebrate HH pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel IKBKG-interacting protein, RUSC1, an adapter molecule previously shown to be involved in the NGF-pathway via the NTRK1
  • RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS