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FLASH GENE

Symbol

RUSC1

contributors: mct - updated : 09-06-2017

HGNC name	RUN and SH3 domain containing 1
HGNC id	17153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21.3      Physical location : 155.290.639 - 155.300.909
Synonym name	nesca protein
	new molecule containing SH3 at the carboxy-terminus
Synonym symbol(s)	NESCA

DNA

TYPE	functioning gene
STRUCTURE	10.27 kb     9 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001105203 10 - 3503 NP_001098673 - 902 - 2012 22404429 NM_001105204 10 - 3185 NP_001098674 - 796 - 2012 22404429 NM_001278228 8 - 2705 NP_001265157 - 427 - 2012 22404429 NM_014328 9 - 2568 NP_055143 - 433 - 2012 22404429 NM_001278229 9 - 2250 NP_001265158 - 327 - 2012 22404429 NM_001278227 9 - 2469 NP_001265156 - 400 - 2012 22404429 NM_001105205 9 - 2525 NP_001098675 - 496 - 2012 22404429 NM_001278230 8 - 2367 NP_001265159 - 433 - 2012 22404429

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Homo sapiens Fetal Respiratory lung         Visual eye         Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

IMPRINTING	paternally
text	expressed maternally (from maternally inherited transcripts)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RUN domain at its N-terminus, that can bind H-Ras, a downstream signaling molecule of NTRK1, with high affinity
	a leucine zipper motif,
	no catalytic domain
	one VWFC domain
	a C-terminal SH3 domain

mono polymer

homomer , trimer

HOMOLOGY

Homologene

FAMILY

Rusc family of proteins

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus

basic FUNCTION	putative adapter protein
	functions as an adapter involved in neuronal vesicular transport including vesicles containing soluble N-ethylmaleimide sensitive factor attachment protein receptors that are essential to exocytosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

	RUSC1 participates in the NGF-NTRK1 signaling pathway
	RUSC1 and RUSC2 are novel components of the vertebrate HH pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	novel IKBKG-interacting protein, RUSC1, an adapter molecule previously shown to be involved in the NGF-pathway via the NTRK1
	RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS