Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FHL5 contributors: mct - updated : 27-01-2010
HGNC name four and a half LIM domains 5
HGNC id 17371
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four cysteine-rich LIM/double finger motifs, each containing two zinc finger motifs
  • half LIM extrafinger domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Act
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • during spermatid elongation, it localizes to the nucleus of round spermatids but exits the nucleus to the cytoplasm as cells differentiate to elongated spermatids
    • basic FUNCTION
  • coactivator putatively involved in distinct cellular differentiation programm
  • activates CREM in a phosphorylation-independent fashion
  • required for normal sperm maturation and morphology, is not essential for testicular gene expression
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CREM–FHL5 complex mediates the expression of many post-meiotic genes that are essential for normal spermatogenesis, thus providing a tissue-specific modulation mechanism for CREM transcription activity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating CREB and CREM independently of CREBBP
  • KIF17b (interaction restricted to specific stages of spermatogenesis)
  • interact with CREM, a DNA binding transcriptional regulator necessary for spermiogenesis
  • interacts with SPAG8, which suggests that SPAG8 could be associated with FHL5 during spermatogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to male factor subfertility
  • to astrocytosis and rapid cognitive decline in Alzheimer disease
    • Variant & Polymorphism other
  • different haplotypes may contribute to male factor subfertility
  • SNP associated with astrocytosis and rapid cognitive decline in AD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS