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FLASH GENE

Symbol

FHL5

contributors: mct - updated : 27-01-2010

HGNC name	four and a half LIM domains 5
HGNC id	17371

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020482 7 - 2135 NP_065228 - 284 - 1999 10086359 NM_001170807 6 - 1904 NP_001164278 - 284 - 1999 10086359

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain medulla oblongata       brain diencephalon hypothalamus     Reproductive male system testis

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid Reproductive spermatocyte

cell lineage
cell lines	carcinomas, melanomas and leukemias
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four cysteine-rich LIM/double finger motifs, each containing two zinc finger motifs
	half LIM extrafinger domain

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to murine Act

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	during spermatid elongation, it localizes to the nucleus of round spermatids but exits the nucleus to the cytoplasm as cells differentiate to elongated spermatids

basic FUNCTION	coactivator putatively involved in distinct cellular differentiation programm
	activates CREM in a phosphorylation-independent fashion
	required for normal sperm maturation and morphology, is not essential for testicular gene expression

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CREM–FHL5 complex mediates the expression of many post-meiotic genes that are essential for normal spermatogenesis, thus providing a tissue-specific modulation mechanism for CREM transcription activity

INTERACTION

DNA

RNA

small molecule

protein	activating CREB and CREM independently of CREBBP
	KIF17b (interaction restricted to specific stages of spermatogenesis)
	interact with CREM, a DNA binding transcriptional regulator necessary for spermiogenesis
	interacts with SPAG8, which suggests that SPAG8 could be associated with FHL5 during spermatogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to male factor subfertility to astrocytosis and rapid cognitive decline in Alzheimer disease

Variant & Polymorphism other	different haplotypes may contribute to male factor subfertility
	SNP associated with astrocytosis and rapid cognitive decline in AD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS