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FLASH GENE
Symbol FHL5 contributors: mct - updated : 27-01-2010
HGNC name four and a half LIM domains 5
HGNC id 17371
Location 6q16.1      Physical location : 97.010.423 - 97.064.512
Synonym name
  • four and a half LIM domain protein 4
  • LIM protein ACT
  • activator of cAMP-responsive element modulator (CREM) in testis
  • activator of CREM in testis
    • Synonym symbol(s) FHL4, FLJ33049, ACT, dJ393D12.2, 1700027G07Rik, KIAA0776, RP3-393D12.2
    DNA
    TYPE functioning gene
    STRUCTURE 54.08 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2135 - 284 - 1999 10086359
    6 - 1904 - 284 - 1999 10086359
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
     braindiencephalonhypothalamus  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines carcinomas, melanomas and leukemias
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteine-rich LIM/double finger motifs, each containing two zinc finger motifs
  • half LIM extrafinger domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Act
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • during spermatid elongation, it localizes to the nucleus of round spermatids but exits the nucleus to the cytoplasm as cells differentiate to elongated spermatids
    • basic FUNCTION
  • coactivator putatively involved in distinct cellular differentiation programm
  • activates CREM in a phosphorylation-independent fashion
  • required for normal sperm maturation and morphology, is not essential for testicular gene expression
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CREM–FHL5 complex mediates the expression of many post-meiotic genes that are essential for normal spermatogenesis, thus providing a tissue-specific modulation mechanism for CREM transcription activity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating CREB and CREM independently of CREBBP
  • KIF17b (interaction restricted to specific stages of spermatogenesis)
  • interact with CREM, a DNA binding transcriptional regulator necessary for spermiogenesis
  • interacts with SPAG8, which suggests that SPAG8 could be associated with FHL5 during spermatogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to male factor subfertility
  • to astrocytosis and rapid cognitive decline in Alzheimer disease
    • Variant & Polymorphism other
  • different haplotypes may contribute to male factor subfertility
  • SNP associated with astrocytosis and rapid cognitive decline in AD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS