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FLASH GENE
Symbol NAALAD2 contributors: mct - updated : 19-02-2018
HGNC name N-acetylated alpha-linked acidic dipeptidase 2
HGNC id 14526
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal transmembrane domain
  • a central region involved in the NAALADase activity
  • the dipeptidyl peptidase IV type activity in the C-terminal region
  • seven potential N-glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Naalad2 (88.4 pc)
    homolog to murine Naalad2 (88.1 pc)
    Homologene
    FAMILY
  • peptidase M28 family
  • M28B subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • having N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity
  • also exhibiting a dipeptidyl-peptidase IV type activity
  • inactivating the peptide neurotransmitter N-acetylaspartylglutamate
  • acting as a metallopeptidase
  • playing a role of serine-type peptidase
  • forms likely a labile catalytic Zn-Ca cluster that is critical for its beta-citrylglutamate hydrolase activity
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+ (binding 2 ions per subunit)
    • protein
    cell & other
    REGULATION
    inhibited by quisqualate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS