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FLASH GENE

Symbol

NAALAD2

contributors: mct - updated : 19-02-2018

HGNC name	N-acetylated alpha-linked acidic dipeptidase 2
HGNC id	14526

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     predominantly Hearing/Equilibrium ear       highly Nervous brain         Reproductive female system ovary         male system testis     highly   male system prostate     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	moderately in embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal transmembrane domain
	a central region involved in the NAALADase activity
	the dipeptidyl peptidase IV type activity in the C-terminal region
	seven potential N-glycosylation sites

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Naalad2 (88.4 pc)
	homolog to murine Naalad2 (88.1 pc)

Homologene

FAMILY	peptidase M28 family
	M28B subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	single-pass type II membrane protein

basic FUNCTION	having N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity
	also exhibiting a dipeptidyl-peptidase IV type activity
	inactivating the peptide neurotransmitter N-acetylaspartylglutamate
	acting as a metallopeptidase
	playing a role of serine-type peptidase
	forms likely a labile catalytic Zn-Ca cluster that is critical for its beta-citrylglutamate hydrolase activity

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Zn2+ (binding 2 ions per subunit)

protein

cell & other

REGULATION

inhibited by

quisqualate

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS