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FLASH GENE
Symbol RECK contributors: mct/npt - updated : 23-01-2017
HGNC name reversion-inducing-cysteine-rich protein with kazal motifs
HGNC id 11345
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five knot repeat
  • three kazal-like domains (K23 motif)
  • cystein rich domain
  • three protase inhibitor-like domain
  • two EGFR-like domains
  • five N-glycosylation sites
    • conjugated GlycoP , LipoP
    mono polymer heteromer , complex
    isoforms Precursor a 26 aa signal peptide of 2.5 kda, a 945 aa mature peptide of 104 kda
    HOMOLOGY
    interspecies homolog to rattus Reck (92.4 pc)
    homolog to murine Reck (93.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • lipid-anchor
  • GPI-anchor
    • basic FUNCTION
  • acting as a negative regulator for matrix metalloproteinase 9 and 2 (MMP9, MMP2)
  • inhibiting tumor invasion
  • acting as a serine-type endopeptidase inhibitor
  • regulates the ectodomain shedding of Notch ligands by directly inhibiting the proteolytic activity of ADAM10
  • inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development (Muraguchi 2007)
  • inhibits the enzymatic activities of some matrix metalloproteinases (MMP), thereby suppressing tumor cell metastasis (Takagi 2009)
  • critically regulates Notch signaling by antagonizing the ectodomain shedding of Notch ligands, which is mediated by a disintegrin and metalloproteinase domain 10 (ADAM10) (Muraguchi 2007)
  • GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text negative regulation of progression through cell cycle
    PATHWAY
    metabolism
    signaling
    a component
  • N-glycosylated
  • forming a complex with MT1-MMP
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MMP9 (negative regulator of MMP9 transcription) (Takagi 2009)
  • interacting with Tgat oncoprotein
  • cleaved by MMP2 and MMP7 and competitively inhibits MMP-7-catalyzed cleavage of fibronectin (Omura 2009)
  • RECK and GPR124 are part of the cell surface protein complex that transduces WNT7A- and WNT7B-specific signals in mammalian CNS endothelial cells (ECs) to promote angiogenesis and regulate the Blood-Brain Barrier
    • cell & other
    REGULATION
    inhibited by Tgat oncoprotein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    downregulation caused by promoter methylation in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target K23 motifs of RECK protein can inhibit MMP9 secretion and activity and attenuate metastasis of lung cancer cells (Chang 2008)
    ANIMAL & CELL MODELS