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FLASH GENE

Symbol

BTG4

contributors: mct/npt - updated : 02-09-2020

HGNC name	B-cell translocation gene 4
HGNC id	13862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ZCF1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly reduced in primary gastric cancer by hypermethylation but not in normal gastric tissues (Dong 2009) tumoral fusion       with POU2AF1 in t(11;13)(q23;q12) in chronic lymphocytic leukemia

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers (Dong 2009)
Marker
Therapy target

ANIMAL & CELL MODELS

	Btg4 null female mice produce morphologically normal oocytes that, due to the accumulation of maternal mRNAs, arrest at the one-cell stage after fertilization
	Btg4-null females produced morphologically normal oocytes but were infertile, owing to early developmental arrest