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FLASH GENE
Symbol BTG4 contributors: mct/npt - updated : 02-09-2020
HGNC name B-cell translocation gene 4
HGNC id 13862
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal domain spanning 104-106 AAs, a protein-protein interaction module, which is capable of binding to DNA-binding transcription factors as well as the paralogues CNOT7 (human Caf1/Caf1a) and CNOT8 (human Pop2/Calif/Caf1b), two deadenylase subunits of the Ccr4-Not complex (Winkler 2010)
  • potential phosphorylation sites for protein kinase C
  • casein kinase 2
  • two conserved regions—the N-terminal BTG domain that contains the Box-A and Box-B motifs
  • C-terminal regions are less conserved and appear to mediate protein-protein interactions that are unique to each family member
    • HOMOLOGY
    interspecies ortholog to murine Pc3b
    Homologene
    FAMILY
  • Tob/TBG1 family of growth inhibitory gene
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • antiproliferative activity, being able to induce G(1) arrest
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover (Winkler 2010)
  • is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes
  • is an essential regulator of metaphase II arrest
  • BTG4-dependent pathway for controlling poly(A) tail length during meiosis with an unexpected role for mRNA deadenylation in preventing the spontaneous activation of eggs
  • role of BTG4 in human early embryonic development
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text differentiation of olfactory epithelium (mouse
    PATHWAY
    metabolism
    signaling
    a component
  • complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
  • BTG4 is a novel TP53-regulated gene and probably functions as a tumor suppressor in lung and colorectal cancers
  • BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ZCF1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly reduced in primary gastric cancer by hypermethylation but not in normal gastric tissues (Dong 2009)
    tumoral fusion      
    with POU2AF1 in t(11;13)(q23;q12) in chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers (Dong 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Btg4 null female mice produce morphologically normal oocytes that, due to the accumulation of maternal mRNAs, arrest at the one-cell stage after fertilization
  • Btg4-null females produced morphologically normal oocytes but were infertile, owing to early developmental arrest